A large-scale analysis published in JAMA Network Open confirms that structured medication review programs can significantly and safely reduce the use of potentially inappropriate medications in older adults. The findings are based on a review of 178 randomized clinical trials involving more than 30,000 participants.

Key takeaways from the study include:

• Meaningful reduction in drug burden
  Medication review programs, especially those led by pharmacists, were shown to substantially reduce the number of inappropriate or unnecessary medications in older adults.
• Safety maintained during deprescribing
  The reduction in medication use did not lead to an increase in adverse health events, suggesting these programs can be implemented without compromising patient safety.
• Wide-ranging applicability
  The benefits were observed across multiple care settings, including hospitals, primary care, and long-term care facilities, making the approach broadly applicable in senior care.
• Team-based approach is most effective
  Programs involving multidisciplinary collaboration—often between physicians, pharmacists, and nursing staff—achieved the most significant results.
• Impact on quality of life
  Reducing unnecessary medications can improve patient outcomes by minimizing side effects, lowering the risk of drug interactions, and simplifying medication regimens.
  

The authors conclude that medication review programs are an effective, evidence-based intervention to optimize prescribing for older adults, with benefits that extend across healthcare settings.